Confidence intervals and point estimates for treatment effects in adaptive enrichment designs
Statistical Methods in Medical Research: An International Review Journal
Published online on February 24, 2026
Abstract
Statistical Methods in Medical Research, Ahead of Print.
Adaptive enrichment designs allow subgroup selection of the patient population within a confirmatory trial via an interim analysis. However, this design complicates treatment effect estimation and uncertainty quantification. This paper introduces ap-value ...
Adaptive enrichment designs allow subgroup selection of the patient population within a confirmatory trial via an interim analysis. However, this design complicates treatment effect estimation and uncertainty quantification. This paper introduces ap-value ...