A randomized open-label multicentre clinical trial comparing single-anastomosis duodenal switch (SADI-S) versus Roux-en-Y gastric bypass for the treatment of severe obesity: BYPSADIS study protocol

Javier Osorio, Claudio Lazzara, Marta Guimaraes, Antonio Torres, Victor Turrado-Rodríguez, Ainitze Ibarzabal, Lucia Sobrino, Mario Nora, Nuria Vilarrassa, Ana de Hollanda, Miguel A. Rubio-Herrera, Josep Vidal, Violeta Moizé, Concepción Yarnoz, Isabel Fernandez-Falop, Manuel Portillo, Andrés Sánchez-Pernaute

Scandinavian Journal of Surgery

Published online on October 17, 2025

Abstract

Scandinavian Journal of Surgery, Volume 115, Issue 1, Page 119-128, March 2026.
Background:Roux-en-Y gastric bypass (RYGB) is a standard bariatric surgical technique, associated with suboptimal response and recurrent weight gain in 25%–50% of cases. Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a ...