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The ‘power of 1’: The ethics and epistemology of ‘N-of-1 trials’ in oncology

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Research Ethics

Published online on

Abstract

Research Ethics, Ahead of Print.
Conduct of clinical research involving single patient subjects has a relatively long history. The notion of ‘N-of-1 trials’ first emerged in the 1980s, introducing a method for evaluating the impact of alternately exposing individuals ‘on’ and ‘off’ a ...