Formaldehyde is released from cyanoacrylate adhesives used in venous occlusion systems

Joseph Gracé, David E. Connor, Richard O. Day, Martin P. Bucknall, Andrew Jenner, Danijela Kocic, Thomas Exner, Kurosh Parsi, Phlebology and Fluid Mechanics Research Laboratory, St Vincent, s Centre for Applied Medical Research , St Vincent, s Hospital, Faculty of Medicine and Health, The University of New South Wales, Therapeutics Centre, St Vincent, s Hospital Sydney, Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, The University of New South Wales, Clinical Pharmacology and Toxicology, St Vincent, s Hospital Sydney, Haematex Research, Department of Dermatology, St Vincent, s Hospital Sydney

Phlebology: The Journal of Venous Disease

Published online on January 16, 2026

Abstract

Phlebology, Ahead of Print.
ObjectivesCommercially available cyanoacrylates are known to release formaldehyde during degradation. However, it is unknown whether venous adhesive cyanoacrylates used in the treatment of saphenous veins release formaldehyde. Formaldehyde is a known ...