Mitochondrial-related pathogenic genes in varicose veins: A multi-omics Mendelian randomization study

Xiaoyun Tan, Zhenyin Liu, Kunshan Chen, Dan Li, Jiejun Xia, Chuanqiang Niu, Haibo Li, Jianzhong Huang, Department of Interventional Radiology , Vascular Anomalies, Guangzhou Women and Children, s Medical Center, Guangzhou Medical University, Department of Ultrasound Medicine, Liwan Central Hospital of Guangzhou

Phlebology: The Journal of Venous Disease

Published online on November 10, 2025

Abstract

Phlebology, Ahead of Print.
ObjectivesThe dysfunction of mitochondria has been associated with the development of varicose veins (VV), but the specific mitochondrial-related genes and their roles in VV have not been fully elucidated. We employed Mendelian randomization (MR) and ...