Efficacy of autologous platelet-rich fibrin compared to normal saline in the management of chronic venous leg ulcers: A randomized controlled trial

Pallaprolu Jyothirmai, Jitendra Kumar Kushwaha, Saumya Singh, Tulika Chandra, Shailendra Kumar Yadav, Krishna Kant Singh, Abhinav Arun Sonkar, Department of General Surgery, King George, s Medical University, Uttar Pradesh , Department of Transfusion Medicine, King George, s Medical University, Uttar Pradesh , Department of Thoracic Surgery, King George, s Medical University, Uttar Pradesh

Phlebology: The Journal of Venous Disease

Published online on March 12, 2026

Abstract

Phlebology, Ahead of Print.
ObjectiveTo compare the efficacy of Autologous Platelet-Rich Fibrin (PRF) versus Normal Saline (NS) dressings in healing Chronic Venous Leg Ulcers (CVLUs), focusing on ulcer area reduction and quality of life.MethodsA randomized controlled trial was ...