PAI-1 Inhibition in experimental venous thrombosis

Maxim E. Shaydakov, Cory D. Emal, Joshua P. Rainey, Daniel A. Lawrence, Jose A. Diaz, Vascular and Endovascular Surgery, WellSpan Health, Conrad Jobst Research Vascular Laboratories, University of Michigan Medical School, Ann Arbor, Department of Chemistry, Eastern Michigan University, Department of Orthopedic Surgery, University of Utah Health Hospitals and Clinics, Salt Lake City, Internal Medicine, University of Michigan Medical School, Ann Arbor

Phlebology: The Journal of Venous Disease

Published online on January 22, 2026

Abstract

Phlebology, Ahead of Print.
BackgroundA novel PAI-1 inhibitor, MDI-2268, has been recently developed. The aim of the study was to evaluate the antithrombotic effects and safety of the MDI-2268 in acute venous thrombosis (VT) in vivo.MethodsC57BL/6 mice, 10–12 weeks old, weighing 20–...