Staged mechanical circulatory support in paediatric HIT: Bivalirudin anticoagulation across ECMO, VAD, and cardiac transplantation

Arun Beeman, Richard W. Issitt, Mary Mathias, Marc Cohen, Craig Laurence, Nagarajan Muthialu, Martin Kostolny, Timothy Thiruchelvam, Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, Department of Perfusion, Great Ormond Street Hospital for Children, Department of Haemophilia Centre, Great Ormond Street Hospital for Children, Department of Anaesthesia, Great Ormond Street Hospital for Children, Department of Transplantation, Great Ormond Street Hospital for Children, Department of Cardiothoracic Intensive Care, Great Ormond Street Hospital for Children

Perfusion

Published online on December 27, 2025

Abstract

Perfusion, Ahead of Print.
IntroductionHeparin induced thrombocytopenia (HIT) with in paediatric population is rare and subsequent anticoagulation management is challenging. Bivalirudin is a viable alternative to heparin for anticoagulating paediatric patients with HIT, though ...