Sulodexide protected the heart against ischemia/reperfusion injury by reducing oxidative stress, inflammation, and apoptosis in the isolated rat heart

Savas Ustunova, Rezan Aksoy, Aysu Kilic, Huri Demirci, Murat Bulent Rabus, Ahmet Kursat Bozkurt, Cengiz Koksal, Department of Physiology, School of Medicine, Bezmialem Vakif University, Department of Cardiovascular Surgery, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Education and Research Hospital, University of Health Sciences, Department of Medical Biochemistry, School of Medicine, Biruni University, Department of Cardiovascular Surgery, Kosuyolu High Specialization Education and Research Hospital, University of Health Sciences, Department of Cardiovascular Surgery, Istanbul University - Cerrahpasa Medical Faculty, Department of Cardiovascular Surgery, Medipol Acibadem Hospital

Perfusion

Published online on February 17, 2026

Abstract

Perfusion, Ahead of Print.
IntroductionThis study aimed to investigate the antioxidant effects of suledoxide (SDX) on myocardial tissue in ischemia-reperfusion (IR) injury using the Langendorff heart system.MethodsRat hearts were studied with the Langendorff technique and subjected ...