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Cumulative elevation of aPTT predicts time to major bleeding and death in ECMO: A joint longitudinal-survival model

Perfusion

Published online on

Abstract

Perfusion, Ahead of Print.
IntroductionAnticoagulation management during extracorporeal membrane oxygenation (ECMO) remains an important challenge, with bleeding rates reaching 30%. Activated partial thromboplastin time (aPTT) is the most used biomarker for heparin titration, ...