Exploring weaning-related shock: Cardiac injury and overload, platelet-endothelial cell activation, and inflammatory response markers following ECMO decannulation

Lara C.A. Pladet, Carlos V. Elzo Kraemer, Stefan Nierkens, Jeannine A. Hermens, Emma Rademaker, Lennie P.G. Derde, Christiaan L. Meuwese, Dirk W. Donker, Olaf L. Cremer, Department of Intensive Care Medicine, University Medical Center Utrecht, The Netherlands, Department of Intensive Care Medicine, Leiden University Medical Center, The Netherlands, Center for Translational Immunology, University Medical Center Utrecht, The Netherlands, Princess Máxima Center for Pediatric Oncology, The Netherlands, Julius Center, University Medical Center Utrecht, The Netherlands, Department of Intensive Care, Erasmus Medical Center Rotterdam, The Netherlands, Cardiovascular and Respiratory Physiology, TechMed Center, University of Twente, The Netherlands

Perfusion

Published online on April 06, 2026

Abstract

Perfusion, Ahead of Print.
IntroductionMortality in patients receiving Extracorporeal Membrane Oxygenation (ECMO) is partly attributable to unanticipated hemodynamic instability after elective decannulation, termed weaning-related shock (WRS). This study explored the etiology of ...