Optimizing the Approach to Calculating CST Lesion Load in Ischemic Stroke Patients for Understanding Motor Outcomes

Brady J. Williamson, Tyler Behymer, Anne Schwarz, Achala Vagal, Carolee J. Winstein, Michael R. Borich, Colleen Hanlon, Michael Dimyan, Adriana B. Conforto, Fabrizio Piras, Daniela Vecchio, Brenton Hordacre, Lara A. Boyd, Jennifer K. Ferris, Jessica M. Cassidy, Sophia I. Thomopoulos, Neda Jahanshad, Paul M. Thompson, Mahir Khan, Sook-Lei Liew, Steven C. Cramer

Neurorehabilitation and Neural Repair: An International Journal of Translational Science for Researchers and Clinicians

Published online on March 02, 2026

Abstract

Neurorehabilitation and Neural Repair, Volume 40, Issue 6, Page 448-460, June 2026.
IntroductionCorticospinal tract lesion load (CST-LL) is a biomarker used for studying motor outcomes after stroke. However, the optimal method for calculating this metric is unknown.MethodsThis is a cross-sectional study of a large ischemic stroke cohort ...