A Novel Radiographic and Genetic Variant of Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Case Report

Ariadne A. Nichol, Angeline B. Ngo, Meshari Alharthi, Kari Hird, Mallory Owen, Sophia Raefsky, Jennifer H. Yang, Department of Neurosciences, University of California San Diego, La Jolla, Department of Internal Medicine, Umm Al-Qura University, Saudi Arabia, Department of Pathology, University of California San Diego, La Jolla

The Neurohospitalist

Published online on September 09, 2025

Abstract

The Neurohospitalist, Volume 16, Issue 2, Page 197-203, April 2026.
BackgroundThe differential for acute onset progressive leukoencephalopathy in adults is broad. Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a rare genetic white matter disorder with typical onset around 40 years. Variability ...