Progressive Multiple Cranial Neuropathies as a Manifestation of CAR-T Neurotoxicity

Zachary T. Lazzari, Avi Singh Gandh, Bhagya Sannananja, Samir R. Belagaje, Spencer K. Hutto, Department of Neurology, School of Medicine, Emory University, Department of Radiology, School of Medicine, Emory University

The Neurohospitalist

Published online on October 25, 2025

Abstract

The Neurohospitalist, Volume 16, Issue 2, Page 233-237, April 2026.
To describe a case of delayed onset multiple cranial neuropathies as a manifestation of neurotoxicity after chimeric antigen receptor T-cell (CAR-T) therapy for multiple myeloma. While ICANS following CAR-T is a well-reported complication, it classically ...