Neutralizing autoantibodies against interferon alpha in systemic lupus erythematosus: Prevalence, age of onset, and clinical associations

Elsa Grenmyr, Birgitta Gullstrand, Andreas Jern, Niklas Björklund, Robin Kahn, Fredrik Kahn, Petrus Linge, Andreas Jönsen, Anders A. Bengtsson, Department of Clinical Sciences, Lund University and Skåne University Hospital, Department of Clinical Sciences, Pediatrics and Wallenberg Centre for Molecular Medicine, Lund University and Skåne University Hospital, Department of Clinical Sciences, Infection Medicine and Wallenberg Centre for Molecular Medicine, Lund University and Skåne University Hospital

Lupus: An International Journal

Published online on March 06, 2026

Abstract

Lupus, Volume 35, Issue 6, Page 623-629, May 2026.
ObjectiveType I interferons (IFN) drive systemic lupus erythematosus (SLE) pathogenesis. Some patients develop neutralizing IFN autoantibodies (anti-IFN ab), which theoretically could modify disease activity. We aimed to determine the prevalence of anti-...