Beyond glomeruli in lupus nephritis: Impact of tubulointerstitial inflammation and interstitial fibrosis/tubular atrophy on renal function decline – A systematic review and meta-analysis

Kenzo Ogasawara Donato, Akio Ogasawara Donato, Lucas Ferraz Gonçalves, Pedro Maia, Gustavo Garrido, Philippe Quadros, André Nishizima, Laura Mesquita, Adriano Mota, Gabriel Jacob Moreno, Alleh Nogueira, Carlos Antonio Moura, Department of Medicine, Bahiana School of Medicine and Public Health, Department of Medicine, Federal University of Bahia, Department of Medicine, Salvador University , Department of Medicine, Dom Pedro University, Postgraduate Program in Cardiology, Federal University of Rio Grande do Sul , Porto Alegre, Department of Internal Medicine, Santo Antônio Hospital , Irmã Dulce Social Works

Lupus: An International Journal

Published online on March 20, 2026

Abstract

Lupus, Ahead of Print.
BackgroundTo evaluate the prognostic impact of tubulointerstitial inflammation and interstitial fibrosis/tubular atrophy on renal function decline in patients with lupus nephritis.MethodsThis systematic review and meta-analysis followed PRISMA and ...