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Tembleque (SDtq) rat: A new model of leukodystrophy associated with hypomyelination and impaired oligodendrocyte maturation

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Laboratory Animals: The international journal of laboratory animal science and welfare

Published online on

Abstract

Laboratory Animals, Volume 60, Issue 1, Page 63-74, February 2026.
This work presents the characterization oftembleque(SDtq) rats as a novel animal model for myelination abnormalities, primarily manifesting as tremors and ataxia, which notably declined by 16 weeks of age. This model originated from a spontaneous ...