Differential metabolism of citalopram by 21 CYP3A4 variants: An in vitro experiment
Published online on October 28, 2025
Abstract
Journal of Psychopharmacology, Volume 39, Issue 12, Page 1387-1396, December 2025.
Background:Citalopram is widely used for treating major depressive disorder, but exhibits substantial inter-individual variation in clinical response. CYP3A4 is one of the cytochrome P450 enzymes (CYP450) involved in the demethylation metabolism of ...
Background:Citalopram is widely used for treating major depressive disorder, but exhibits substantial inter-individual variation in clinical response. CYP3A4 is one of the cytochrome P450 enzymes (CYP450) involved in the demethylation metabolism of ...