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The unique efficacy of clozapine is attributable to muscarinic receptor agonism

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Journal of Psychopharmacology

Published online on

Abstract

Journal of Psychopharmacology, Ahead of Print.
Clozapine is superior to all other antipsychotic drugs for treatment-resistant schizophrenia, but the molecular underpinnings for this have remained elusive for decades. Recently, we proposed a cholinergic mechanism, based on the distinct pharmacology of ...