α5-GABAA allosteric modulation triggers and prolongs dopamine neuronal activity via AMPA receptors
Published online on February 17, 2026
Abstract
Journal of Psychopharmacology, Ahead of Print.
Background:Negative allosteric modulators (NAMs) of gamma-aminobutyric acid (GABAA) receptors targeting the α5-subunit, primarily expressed on glutamate pyramidal neurons in the hippocampus and cortex, reduce inhibitory tone and enhance α-amino-3-hydroxy-...
Background:Negative allosteric modulators (NAMs) of gamma-aminobutyric acid (GABAA) receptors targeting the α5-subunit, primarily expressed on glutamate pyramidal neurons in the hippocampus and cortex, reduce inhibitory tone and enhance α-amino-3-hydroxy-...