Precision dosing of clozapine: A physiologically based pharmacokinetic/pharmacodynamic model integrating genetic polymorphisms and clinical outcomes
Published online on March 09, 2026
Abstract
Journal of Psychopharmacology, Ahead of Print.
Background:The efficacy of clozapine in treatment-resistant schizophrenia is limited by significant pharmacokinetic variability due to genetic polymorphisms, drug interactions, and environmental factors, necessitating personalized dosing strategies.Aims:...
Background:The efficacy of clozapine in treatment-resistant schizophrenia is limited by significant pharmacokinetic variability due to genetic polymorphisms, drug interactions, and environmental factors, necessitating personalized dosing strategies.Aims:...