Retrospective, Single-Center Evaluation of Dose Tapering Strategies of Dexamethasone in Hospitalized Patients With Malignant Spinal Cord Compression

Drew A. Wells, Samuel C. Greer, Kerri Jones, Allison Huisingh, Sami Sakaan, Department of Pharmacy, Methodist Le Bonheur Healthcare , University Hospital, Department of Clinical Pharmacy and Translational Science, The University of Tennessee Health Science Center College of Pharmacy, Department of Pharmacy, Union University College of Pharmacy

Journal of Pharmacy Practice

Published online on January 12, 2026

Abstract

Journal of Pharmacy Practice, Ahead of Print.
Background:Historical trials of adjunctive dexamethasone for management of neurologic symptoms in malignant spinal cord compression (MSCC) utilized high doses of dexamethasone for 3 days then tapered over an additional 12 days. There is limited evidence ...