Vascular endothelial cell–derived small extracellular vesicles: A protective role against cardiomyocyte apoptosis in ischemia–reperfusion injury through miR410-3p-modulated smad7 pathway

Xiaoqiang Liu, Yulong Ge, Xing Xing, Junyi Liu, Hangwei Chen, Di Wang, Huaner Ni, Weifeng Li, Fang WangDepartment of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Journal of International Medical Research

Published online on April 16, 2026

Abstract

Journal of International Medical Research, Volume 54, Issue 4, April 2026.
ObjectiveReperfusion therapy is essential for preserving cardiac tissue in patients with acute myocardial infarction. However, ischemia–reperfusion exacerbates cardiac damage. Vascular endothelial cell–derived small extracellular vesicles play a pivotal ...