A novel low-metabolism strategy combined with multimodal detoxification for successful management of high-dose diquat–paraquat mixed poisoning: A comprehensive therapeutic analysis

Zhenhua Li, Zhiyuan Cen, Jing Wei, Gui Huang, Kai Mo, Huaixing Yan, Lijian Liang, Haihua Du, Xinwen Mai, Shixiong Yang, Shizhuang Wei, Wei Wang, Department of Emergency Medicine, the Fifth Affiliated Hospital of Guangxi Medical University , The First People, s Hospital of Nanning, Intensive Care Unit, the Fifth Affiliated Hospital of Guangxi Medical University , The First People, s Hospital of Nanning, Nanning Center for Toxicology and Poison Control, Department of Pharmacy, the Fifth Affiliated Hospital of Guangxi Medical University , The First People, s Hospital of Nanning, Department of Emergency, the First Affiliated Hospital of Guangxi Medical University

Journal of International Medical Research

Published online on April 30, 2026

Abstract

Journal of International Medical Research, Volume 54, Issue 4, April 2026.
Combined diquat and paraquat poisoning is a rare but clinically significant form of poisoning, associated with severe oxidative stress and multiorgan failure. Historical case series have reported high case fatality, particularly following high-dose ...