Ketamine Use in Critically Ill Patients: Insights into Depressive Symptoms and Hemodynamic Changes

Vrutti Patel, Saurabh Sujanyal, Lekhya Raavi, Sophia G. Blumenfeld, Faiz Saleem, Said Bateh, Abby Hanson, Anek Jena, Shahin Isha, Katie L. Kunze, Patrick W. Johnson, Katheleen A. Rottman Pietrzak, Michelle M. Ojard, Ivan A. Huespe, Sadia Z. Shah, Pablo Moreno Franco, Michael A. Edwards, Mohit Chauhan, Devang Sanghavi, Shapiro Anna

Journal of Intensive Care Medicine

Published online on April 16, 2026

Abstract

Journal of Intensive Care Medicine, Ahead of Print.
BackgroundKetamine has demonstrated efficacy in treatment-resistant depression, primarily in psychiatric or outpatient populations. Its use in ICU patients remains underexplored, with limited data beyond case reports and small series. This study evaluated ...