Critically Ill Patients with Severe Cirrhosis Receiving Dexmedetomidine at a Higher Risk of Cardiovascular Instability: Application of an Objective Novel Cirrhosis Scoring System
Journal of Intensive Care Medicine
Published online on December 22, 2025
Abstract
Journal of Intensive Care Medicine, Ahead of Print.
BackgroundDexmedetomidine is a first-line sedative in intensive care unit (ICU) patients. Dexmedetomidine has a high hepatic extraction ratio, where clearance is primarily determined by hepatic blood flow. In cirrhosis, hepatic blood flow is reduced, and ...
BackgroundDexmedetomidine is a first-line sedative in intensive care unit (ICU) patients. Dexmedetomidine has a high hepatic extraction ratio, where clearance is primarily determined by hepatic blood flow. In cirrhosis, hepatic blood flow is reduced, and ...