Mild Behavioral Impairment and Plasma Biomarkers of Neurodegeneration as Predictors of Cognitive Decline in Geriatric Patients With Psychiatric Disorders

Camilla Elefante, Maria Francesca Beatino, Chiara Fustini, Vittoria Lepri, Donatella Acierno, Alessia Scalzo, Lucia Petrozzi, Linda Giampietri, Gloria Tognoni, Filippo Baldacci, Lorenzo Lattanzi, Gabriele Siciliano, Zahinoor Ismail, Roberto Ceravolo, Giulio Perugi, Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Departments of Psychiatry, Clinical Neurosciences, Community Health Sciences, and Pathology and Laboratory Medicine, Hotchkiss Brain Institute , Brien Institute for Public Health, University of Calgary, College of Health and Medicine, University of Exeter

Journal of Geriatric Psychiatry and Neurology

Published online on October 30, 2025

Abstract

Journal of Geriatric Psychiatry and Neurology, Volume 39, Issue 4, Page 413-425, July 2026.
BackgroundMild Behavioral Impairment (MBI) has been increasingly recognized as a potential early clinical marker of neurodegenerative disease, while blood-based biomarkers such as phosphorylated tau 217 (p-tau217) and neurofilament light chain (NfL) are ...