Patients With Older-Age Bipolar Disorder (OABD) Visiting a Memory Clinic: Differentiating Underlying Pathophysiology With MRI and Cerebrospinal Fluid Markers

Alexandra J. M, Everard G. B, Charlotte E. Teunissen, Sigfried N. T, Ralph W. Kupka, Afina W. Lemstra, Annemieke Dols, GGZ inGeest Specialized Mental Healthcare, the Netherlands, Department of Psychiatry, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, the Netherlands, Amsterdam Public Health Research Institute, Mental Health, the Netherlands, Alzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, the Netherlands, Amsterdam Neuroscience, the Netherlands, Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, the Netherlands

Journal of Geriatric Psychiatry and Neurology

Published online on December 06, 2025

Abstract

Journal of Geriatric Psychiatry and Neurology, Volume 39, Issue 5, Page 655-666, September 2026.
BackgroundMany patients with bipolar disorder (BD) report cognitive problems. Pathophysiology of cognitive impairment in BD is unclear, although prevalence of dementia in BD is high. In Older-Age Bipolar Disorder (OABD) patients with cognitive complaints, ...