Maternal Longevity is Associated With Reduced Risk but an Earlier Onset of Alzheimer’s Disease in Offspring

Miguel Tábuas-Pereira, Francisco Mano, Catarina Bernardes, João Durães, Marisa Lima, Kaitlyn DenHaan, Kimberly Paquette, Célia Kun-Rodrigues, Susana Carmona, Teresa Tábuas, Pedro Faustino, Mariana Ruth Coelho, Anuschka Silva-Spínola, Diana Duro, Maria Rosário Almeida, João Malva, Inês Baldeiras, José Brás, Rita Guerreiro, Isabel Santana, Clinical Academic Center of Coimbra , Faculty of Medicine, University of Coimbra, Neurology Department, Centro Hospitalar e Universitário de Coimbra, Centre for Innovative Biomedicine and Biotechnology , Universidade de Coimbra, Dermatology Department, Centro Hospitalar e Universitário de Coimbra, Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Instituto Politécnico de Bragança, Centre for Informatics and Systems, Department of Informatics Engineering, University of Coimbra, Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research , University of Coimbra

Journal of Geriatric Psychiatry and Neurology

Published online on February 16, 2026

Abstract

Journal of Geriatric Psychiatry and Neurology, Ahead of Print.
IntroductionWhile human longevity has increased significantly over the last 2 centuries, the time spent in good physical and cognitive health has not risen proportionately. The incidence of Alzheimer’s disease (AD) increases with age, but parental ...