Alexander Disease: A Literature Review for Clinicians
Published online on March 16, 2026
Abstract
Journal of Child Neurology, Ahead of Print.
Alexander disease (ALEXD; MIM 203450) is a rare leukodystrophy caused by dominant mutations in theGFAP(Glial Fibrillary Acidic Protein) gene, which encodes a key structural protein of astrocytes. First described in 1949, ALEXD is now recognized as a ...
Alexander disease (ALEXD; MIM 203450) is a rare leukodystrophy caused by dominant mutations in theGFAP(Glial Fibrillary Acidic Protein) gene, which encodes a key structural protein of astrocytes. First described in 1949, ALEXD is now recognized as a ...