Evaluation of Phosphohistone H3 in Assessment of Mitotic Activity in Invasive Breast Carcinoma: A Correlative Study With Ki-67 and Histologic Grade

Priyamvada Priyadarshini, Ranjitha Rao, Chaithra GV, Jyoti Kini, Mounika RN, Rakshatha Nayak, Sneha Rao AR, Sunita Hegde, Department of Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education

International Journal of Surgical Pathology

Published online on March 20, 2026

Abstract

International Journal of Surgical Pathology, Volume 34, Issue 5, Page 1170-1179, August 2026.
BackgroundAccurate assessment of tumor proliferation is vital for grading breast cancers, which impacts prognosis. Phosphohistone H3 (PHH3) is a mitotic figure-specific immunohistochemical (IHC) marker. This study aims to evaluate the utility of PHH3 in ...