Event-driven planning of two-armed trials with a binary endpoint
Clinical Trials: Journal of the Society for Clinical Trials
Published online on February 17, 2026
Abstract
Clinical Trials, Volume 23, Issue 2, Page 166-174, April 2026.
Background/Aims:In randomized two-armed clinical trials with binary endpoints, there may be uncertainty about the event probability, which is needed for sample size calculation. Survival trials are powered based on number of events rather than people, and ...
Background/Aims:In randomized two-armed clinical trials with binary endpoints, there may be uncertainty about the event probability, which is needed for sample size calculation. Survival trials are powered based on number of events rather than people, and ...