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Use of estimands in cluster randomised trials: A review

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Clinical Trials: Journal of the Society for Clinical Trials

Published online on

Abstract

Clinical Trials, Volume 23, Issue 2, Page 210-218, April 2026.
Background:An estimand is a clear description of the treatment effect a study aims to quantify. The ICH E9(R1) addendum lists five attributes that should be described as part of the estimand definition. However, the addendum was primarily developed for ...