Response-adaptive randomization with imperfect intermediate endpoints
Clinical Trials: Journal of the Society for Clinical Trials
Published online on February 25, 2026
Abstract
Clinical Trials, Ahead of Print.
Background:Response-adaptive randomization is controversial even in the best circumstances when based on a quickly determined primary outcome. In disease settings in which the primary outcome requires long follow-up, an intermediate endpoint may be chosen ...
Background:Response-adaptive randomization is controversial even in the best circumstances when based on a quickly determined primary outcome. In disease settings in which the primary outcome requires long follow-up, an intermediate endpoint may be chosen ...