Machine learning to optimize precision in the analysis of randomized trials: A journey in pre-specified, yet data-adaptive learning
Clinical Trials: Journal of the Society for Clinical Trials
Published online on February 28, 2026
Abstract
Clinical Trials, Ahead of Print.
Covariate adjustment is an approach to improve the precision of trial analyses by adjusting for baseline variables that are prognostic of the primary endpoint. Motivated by the SEARCH Universal HIV Test-and-Treat Trial (2013–2017), we tell our story of ...
Covariate adjustment is an approach to improve the precision of trial analyses by adjusting for baseline variables that are prognostic of the primary endpoint. Motivated by the SEARCH Universal HIV Test-and-Treat Trial (2013–2017), we tell our story of ...