The evolving role of placebo in non-inferiority trials: A scoping review
Clinical Trials: Journal of the Society for Clinical Trials
Published online on April 06, 2026
Abstract
Clinical Trials, Ahead of Print.
Background:Non-inferiority trials can be used for efficacy endpoints or safety endpoints, with indirect and direct comparison to placebo. A less common application of this design involves using placebo as the proposed intervention to challenge standard ...
Background:Non-inferiority trials can be used for efficacy endpoints or safety endpoints, with indirect and direct comparison to placebo. A less common application of this design involves using placebo as the proposed intervention to challenge standard ...