Quantifying Lupus Anticoagulant Interference in Intrinsic Coagulation Factor Activity Assays and Evaluating the Corrective Performance of the SCT-Based Method

Yu Yang, Yuanyuan Li, Anna Jiang, Yao Lu, Ran You, Linzi Miao, Run Qin, Zijing Zhu, Ying Xing, Chenxue Qu, Department of Clinical Laboratory, Peking University First Hospital

Clinical and Applied Thrombosis/Hemostasis

Published online on February 24, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
BackgroundLupus anticoagulant (LA) prolongs phospholipid-dependent coagulation tests and can falsely reduce intrinsic coagulation factor activities in one-stage assays. The quantitative relationship between LA intensity and the degree of assay ...