Comparative Efficacy and Safety of Non-Clotting Factor Prophylaxis Versus. on-Demand Therapy in Hemophilia: A Meta-Analysis of Randomized Controlled Trials

Rehan Ishaque, Abdul Subhan Talpur, Huda Memon, Laksh Ahuja, Fnu Reya, Amna Ikram, Muhammad Ahsan Siddiqui, Manahil Ali, Hamza Danish, M Raafe Ali Khan, Raghad El joujou, Hamza Janjua, Hira Janjua, Aswanth Reddy, Supratik Rayamajhi

Clinical and Applied Thrombosis/Hemostasis

Published online on March 03, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
IntroductionHemophilia A and B are among the most common inherited bleeding disorders in humans with lifelong risk of spontaneous and recurrent bleeding. While prophylaxis with clotting factors has improved outcomes, challenges like inhibitor development ...