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Smoking, plasma concentration, antipsychotic polypharmacy and adverse drug reaction burden in clozapine outpatients

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Australian & New Zealand Journal of Psychiatry

Published online on

Abstract

Australian & New Zealand Journal of Psychiatry, Volume 60, Issue 5, Page 493-505, May 2026.
Background:Clozapine is the most effective therapy for treatment-resistant schizophrenia, yet adverse drug reactions (ADRs) limit its use. The concurrent ADR burden in outpatients and its relation to psychotropic polypharmacy, tobacco smoking and measured ...