["Developmental Science, Volume 29, Issue 3, May 2026. ", "\nABSTRACT\n\nCanonical babbling, or the production of adult‐like consonant–vowel syllables in infancy, represents a critical milestone in prelinguistic vocal development and predicts later speech and language outcomes. This systematic review and meta‐analysis synthesized findings from 42 studies and 1277 infants aged 5–24 months across 16 language environments to examine how methodological and contextual factors influence the most common measure of canonical babbling: the canonical babbling ratio (CBR). Results confirmed a robust, linear increase in CBR with age, reinforcing its role as a consistent developmental marker. Different CBR measures yielded comparable developmental trajectories. Sampling method significantly affected CBR values, with interactive free‐play sessions eliciting higher CBRs than naturalistic (LENA) home recordings, particularly in older infants. In contrast, the location of data collection had no effect. Ambient language complexity also shaped CBR: Infants acquiring languages with more complex syllable structures (e.g., English, Dutch) initially exhibited lower CBRs compared to infants acquiring languages with less complex syllable structures (e.g., Mandarin, Spanish). Despite these initial differences, babbling trajectories were predicted to converge by approximately 20 months as infants exposed to languages with more complex syllables demonstrated accelerated CBR growth. Publication bias was detected, with smaller samples more likely to report inflated CBRs. To address this issue, simulation‐based analyses are reported to estimate sample size recommendations for improved precision in future research. Together, these results support CBR as a meaningful developmental marker while offering practical guidance for future research directions and continued clinical applications.\n\nSummary\n\nMeta‐analysis of 42 studies with 1277 infants shows canonical babbling ratio (CBR) increases linearly from 0.12 at 5 months to 0.65 at 24 months across language environments.\nAmbient language syllable complexity significantly affects early CBR trajectories, with initial differences converging by 20 months.\nInteractive free‐play sampling methods where caregivers are instructed to “act as they normally do,” consistently elicits higher CBRs than naturalistic, home‐based recordings.\nPublication bias revealed smaller studies report inflated CBR values; simulation analyses provide sample size recommendations for reliable measurement.\n"]