A multi-dimensional earthquake isolation and mitigation device for long-span reticulated structures is a type of newly invented passive control device. In order to acquire the earthquake isolation and mitigation effect of the new devices on long-span reticulated structures under horizontal excitations, the pseudo-dynamic tests for a 1:3 modeled long-span reticulated structure with a size of 3 m x 3 m with and without the devices are carried out. Horizontal dynamic responses of the structure with and without the devices are compared, and the earthquake isolation and mitigation effect of the devices is evaluated under the horizontal excitations. It can be shown from the experimental and finite element numerical results that the proposed new devices have a good effect on earthquake isolation and mitigation on long-span reticulated structures under horizontal earthquake excitations.