The multi-dimensional earthquake isolation and mitigation device (MEIMD) for long-span reticulated structures is a newly invented passive vibration control device. In order to explore the vertical earthquake isolation and mitigation ability of the device, vertical pseudo-dynamic tests on a 1:3 scaled long-span reticulated structure with and without devices are carried out. In the tests, dynamic responses of the structure with the devices are compared with those without the devices under different earthquake waves. It can be seen from experimental results that the devices can obviously reduce the displacement, acceleration, and members’ strain responses of a long-span reticulated structure. Moreover, the finite element analyses are also performed to verify the seismic reduction effect of MEIMD. The numerical results fit well with the experimental results and this indicates that the finite element analysis has high simulation precision.