Explainable machine learning model for predicting acute exacerbations of COPD combining sarcopenia index and traditional risk factors: A retrospective single-center exploratory study

Ai-Bin Zhang, Li-Wen Zhou, Yu-Fen An, Qing-Qing Qin, Jian-Tong Wei, Hao Chen, Pulmonology Respiratory and Critical Care Unit, Gansu Provincial Hospital of Traditional Chinese Medicine, Department of Orthopedics, the First School of Clinical Medicine, Lanzhou University

Chronic Respiratory Disease

Published online on May 20, 2026

Abstract

Chronic Respiratory Disease, Volume 23, January-December 2026.
ObjectivesChronic obstructive pulmonary disease (COPD) is a common respiratory disorder. Acute exacerbation of COPD (AECOPD) severely affects patients’ quality of life and prognosis. This study aimed to identify novel risk factors and develop an effective ...