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Adjunctive xanomeline/trospium in clozapine-resistant schizophrenia: two case reports demonstrating limited response

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Therapeutic Advances in Psychopharmacology

Published online on

Abstract

Therapeutic Advances in Psychopharmacology, Volume 16, XX 2026.
Few pharmacologic options exist for patients with clozapine-resistant schizophrenia (CRS) or schizoaffective disorder. Xanomeline/trospium represents a new class of antipsychotic medication that has efficacy as monotherapy for schizophrenia. Despite ...