Associations of social isolation and loneliness with the risk of adult-onset asthma: A prospective cohort and mendelian randomization study

Juanjuan Zhang, Yuqian Li, Xiangdong Sun, Ruiqi An, Hongjie Zhang, Jianping Gong, Yuanda Zhang, Yijue Li, Yanfeng Gu, Yang Xia, School of Public Health, Hebei University, Hebei Key Laboratory of Public Health Safety, Hebei University, Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Examination Center, Affiliated Hospital of Hebei University, Nutrition Department, Baoding Hospital of Beijing Children, s Hospital, Social Sciences Department, Hebei University

Chronic Respiratory Disease

Published online on March 03, 2026

Abstract

Chronic Respiratory Disease, Volume 23, January-December 2026.
BackgroundDespite proposed aetiological mechanisms involving stress-induced inflammation and behaviour, population-level evidence linking social isolation and loneliness to asthma is lacking. Therefore, we aimed to examine the associations of social ...