Diagnostic performance of FEV1/FEV6 in detecting airway obstruction and chronic obstructive pulmonary disease: A systematic review and meta-analysis

Dongru Du, Sike He, Jiangyue Qin, Hao Wang, Lijuan Gao, Mei Chen, Xiaohua Li, Zhenni Chen, Fengming Luo, Yongchun Shen, Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, Sichuan University, Department of Urology, Institute of Urology, West China Hospital, Sichuan University, General Practice Ward, International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Department of Respiratory and Critical Care Medicine, Sixth People, s Hospital of Chengdu, Department of Medical Administration, West China Hospital, Sichuan University, s Republic of China

Chronic Respiratory Disease

Published online on March 12, 2026

Abstract

Chronic Respiratory Disease, Volume 23, January-December 2026.
BackgroundAlthough the postbronchodilator FEV1/FVC is the gold standard for diagnosing COPD, it is not easily obtainable due to various reasons. This study aims to investigate whether FEV1/FEV6may serve as an easily accessible surrogate for FEV1/FVC in ...