A facile method for the preparation of acid-resistant fabric with the fluoropolymer/SiO₂ hybrid materials was presented. The polyester fabric was treated using a dip-dry technique and, subsequently, cured under high temperature. The results showed that the treated fabric displayed remarkable acid repellency with contact angles of 137.1°, 141.2°, and 139.5° for H₂SO₄ (80%), HCl (30%), and HNO₃ (40%), respectively. The break force tests further confirmed the true potential of fluoropolymer/SiO₂ hybrid materials to fabricate functional textile. We believe that this successful attempt offers an opportunity to fabricate acid-resistant fabric and advances the applications of protective clothing.